Российская академия наук


Features kinesthetic evoked potentials at and patients with a multiple sclerosis and movement disorders



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Features kinesthetic evoked potentials at and patients with a multiple sclerosis and movement disorders

Gordeev S.A., Baziyan B.Kh., Damyanovich E.V.

Research Center of Neurology, Russian Academy of Medical Sciences, Department of Brain Research,

Moscow, e-mail: gordeevsa58@mail.ru.
Studying of changes in the kinesthetic afferent inflow, resulting structural lesions of the skin-motor analyzer, is the major stage on a way of understanding pathogenesis diseases of the nervous system, characterized as disruption of sensory-motor functions.

The purpose of work was studying characteristics of kinesthetic evoked potentials in patients with multiple sclerosis and patients with Parkinson's disease.

29 patients with multiple sclerosis (MS), 16 patients with Parkinson's disease (PD) and 24 healthy control subjects (HCS) with use clinico-neurologic technique and the neurophysiological method of registration kinesthetic evoked potentials (KEP) to passive radiocarpal articulation flexion for 50° with angular acceleration of 350 rad/sec2 were examined.

At the analysis of KEP characteristics in MS patients with disordered deep sensitivity of the upper limbs the expressed change of peak-time parameters of KEP was revealed: significant (p <0.01) increase of the latent period (LP) component P50 and N85 and significant (p <0.05) decrease in amplitude of these component in comparison with HCS.

In 7 MS patients infringements of deep sensitivity neurologic inspection it has not been revealed. Nevertheless, as result of analysis of KEP it was revealed in comparison with HCS significant (p <0.05) increase LP component P50 and N85 at normal values of their amplitude parameters, that most likely, speaks about infringement afferent carrying out in kinesthetic analyzer owing to the begun of demyelinizing process at the given stage of disease. The statistical analysis of parameters KEP in PD patients has revealed authentic changes of early component P50 in the form of its transformation to complex badly differentiated low amplitude positive-negative fluctuations P25-N30-P40-N55-P70.

Conclude, that at patients with MS more substantial growth LP and decrease in amplitude of KEP reflects greater expressiveness of deep sensitivity impairment that allows to state an objective quantitative estimation of a degree of kinesthetic systems defeat. Besides the opportunity of use of a method of KEP registration for objective diagnostics of proprioceptive sensitivity disorders is proved to patients with MS which diseases at an early stage at clinico-neurologic inspection do not come to light. Method KEP can promote more thin studying of the neurophysiological mechanisms underlying disorder of motor functions at Parkinson's disease.



Research is executed at support of the Russian humanitarian scientific fund (the grant № 11-06-00509а).


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