Российская академия наук


SEPARATE AND COMBINED EFFECTS OF DYNAMIC LOADS AND ATROPINE ON GASTRIC SECRETION AMONG ADOLESCENTS AGED 15-16



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SEPARATE AND COMBINED EFFECTS OF DYNAMIC LOADS AND ATROPINE ON GASTRIC SECRETION AMONG ADOLESCENTS AGED 15-16

Davydova S.S, Vakula I.A., Nikitin L.N., Perfilova L.I., Shiryaev Alexander

FGBOU VPO "Lipetsk State Pedagogical University", Lipetsk, Russia, lipetskphisiol@rambler.ru


As we know from the work of I. P. Pavlov and his disciples in the stimulation of gastric secretion major role belongs to cholinergic mechanisms of autonomic regulation. Blockade of M-cholinergic effects on the gastric glands with atropine in our study led to the same degree of inhibition (P <0.01) of all the components of gastric secretion, regardless of the methodology of the study. Blockade of these veloergometric influences on the background of the veloergometeric load capacities of 5,000 kg-m did not alter the inhibitory effect of atropine on the background of the load capacity of 36,900 kgm inhibitory effect of atropine increased. All components of the basal and stimulated gastric secretion significantly decreased in conditions of studying gastric secretion by Veretyanova-Myasfyedova-Novikova method and V.N. Tugolukova method.

Apparently, the stimulating effect of the dosage load on the secretory function of the gastric glands is increasingly realized through the parasympathetic nervous system. Parasympathetic influences, in our view are, largely due to tolerance of gastric glands to the load, as well as to the stability of the gastric mucosa to the aggression factor of gastric juice.

Stopping the M-cholinergic effects blocks not only the direct effect of acetylcholine on the secretory cells of the gastric glands, but also its indirect effect on the G-cells (gastrinovy ​​mechanism), which are called "liberatornoy" role of acetylcholine (in the ratio of gastrin) in the mechanism of secretion gastric proteases. Static load (holding the bar weight on the shoulders) by itself significantly depressed gastric secretion. Isolated atropine caused about the same effect, and in some cases the level of the inhibitory effect of atropine was less pronounced than the degree of the inhibitory effects of stress. Combined effect of load and atropine in all cases was significantly stronger than their isolated effects. Inhibitory effect of static load and atropine in the separate and combined effect spread to basal and stimulated secretion.

In our opinion, a stronger inhibitory effects of static load on gastric secretion tion against atropinovoy blockade of M-cholinergic effects on gastric glands is not only due the inclusion of direct and indirect ( the G-cells) cholinergic effects on the secretory cells of the stomach, but also the braking adrenergic and possibly cholinergic effects on gastric secretion.



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