Российская академия наук


INTERHEMISPHERIC COHERENCE EEG IN PATIENTS WITH NEUROTIC SYMPTOMATOLOGY AND IN PATIENTS WITH EPILEPSI



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INTERHEMISPHERIC COHERENCE EEG IN PATIENTS WITH NEUROTIC SYMPTOMATOLOGY AND IN PATIENTS WITH EPILEPSI

Dokukina T., Misuik N., Minzer M, Korolevich P.

Scientific and practical center of mental health, Minsk, Belarus, e-mail: misuik@mail.ru


The goal of our study was to examine the level of interhemispheric coherence (Coh) in patients suffering from organic pseudoneurotic disorders (OPD) F06.4–F06.6 and F07.1–F07.2 according to ICD-10, neuroses (stress-related disorders) F 4 and epilepsy.

We examined 80 healthy people, 100 patients with organic pseudoneurotic disorders and 67 patients with stress-related disorders aged 18-50. Pseudoneurotic symptomatology in patients with pseudoneurotic disorders was represented with asthenovegetative, asthenodepressive, emotionally labile and anxiety disorders occurring as a result of cerebral injuries, neuroinfections and chronic vascular processes. The same symptomatology was observed in patients with neuroses. The patients with epilepsy have no neurotic symptoms. The study was conducted on encephalograph “Mitsar” in spectral and coherent analysis. 16 electrodes were put over according to the international scheme 10-20.

Patients of all groups showed a significant (р<0,001) decrease of interhemispheric Coh entire range (0,5-30 Гц) between the electrodes Fp1-Fp2, F3-F4, C3-C4, P3-P4 b O1-O2. In patients with neurotic symptoms (neurosis and OPD) reductions Coh in these pairs were relatively even. T-score of differences to healthy patients ranged from 5.9 - 6.5. In patients with symptomatic epilepsy t-test had a clearly defined fronto-occipital gradient. It was 6.13 between occipital electrodes, and 2.88 - between the frontal-pole. Patients with epilepsy between F3-F4 and Fp1-Fp2’s interhemispheric Coh level is significantly (р<0,001) different from the Coh’s level of patients with neurotic symptoms.

The only difference in Coh between the groups of patients with neuroses and OPD was a change between the middle temporal lobe, where patients with neurosis’s Coh was significantly higher (р<0,001) than in healthy patients, patients with OPD and epilepsy, especially in the alpha range.

Probably, Coh largely reflects not the existence and nature of diffuse organic changes in the brain, but the syndrome’s character. Coh’s data reflect the formation of pathological functional system, specific for epileptic syndrome.


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