Российская академия наук

The assessment of anxiety level in rats of impulsive and self-control groups

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The assessment of anxiety level in rats of impulsive and self-control groups.

Zaichenko M.I., Levandovskaya A.A., Merzhanova G.Kh

Institute of higher nervius activity and neurophysiology, Moscow, Russia, mariya-zajchenko@yandex.ru

In studies of impulsivity much attention is paid to the connection between this behavior and various kinds of substantial addictions (Schramm-Sapyta, et al., 2011; Nadal, et al., 2005; Homberg, et al., 2004, etc.). At the same time, a little is known about the relationship of impulsivity with other behavioral features, such as anxiety and exploratory behavior, which are closely related to the addictions of various kinds. J. Gray (Gray, 1981) suggested that anxiety can have a significant impact on the impulsive and under certain conditions involved in the regulatory mechanism of behavioral inhibitory control. But how anxiety and desire for novelty coexist and potentially affect impulsive behavior has been studied only in a few papers.

The aim of this study was to separate the animals into groups "impulsive" and "self-checking" using the technique of choice reinforcement value depending on the time of delivery and to investigate manifestations of anxiety these groups of rats when tested by the method of the elevated plus-maze and the acquisition of the fear-conditioned response.

Rats were divided into 3 groups according to their preference for reinforcements of different values. Animals that preferred valuable but delayed reinforcement in more than70% of cases formed as self-controlled group, less than 30 % of cases formed as impulsive, the rest rats formed ambivalent group. Next animals with different type of behavior were subjected to approximate research activity and anxiety in x-maze and fear-condition. The most active and least alarming were ambivalent animals as compared to self-controlled rats. Between impulsive and self-controlled rats a statistically significant difference in either test were not found. But was shown a tendency for greater research activity measured by the large total distance covered in x-maze and less percent of freezing in fear condition in impulsive animals.

The study was supported by OFPhM “Integrated physiology”, the PRAS Program and “Mechanisms molecular systems integration at the realization of physiological functions”

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