2 Russian State University for the Humanities, L.S.Vygotsky Institute for Psychology
PURPOSE. Pharmacological inhibition of mediodorsal (MD) nucleus suppresses of SWDs and this effect appears specific to the MD. The aim of this study was to investigate effect of bilateral electrostimulation of MD nucleus on pattern of SWDs in WAG/Rij rats.
METHODS. Two groups (n=6 each) were included: low (10 Hz) and high frequency (130 Hz) DBS. All animals were equipped under general anesthesia (chloralhydrate 400 mg/ kg i.p.) with two recording monopolar cortical stainless-steel electrodes placed bilaterally over the frontal cortex and bilateral bipolar stimulation electrodes aimed at the MD nucleus. The rats were stimulated for 1 hrs, the current intensity was 30 % of the threshold amplitude (0.1-0.3 mA, mean 0.2 mA). The duration and number of SWDs were calculated.
ABSTRACT RESULTS. A statistically significant (p<0.05) decrease in the number and duration of SWDs was found after after 10-Hz stimulation, a significant increase of the number and duration of SWDs after 130 Hz stimulation.
ABSTRACT CONCLUSION. Although low frequency stimulation is generally proepileptic, here inhibitory effects were found, probably through an arousing effect. Interestingly, high frequency stimulation showed proepi-
leptic effects. This is in contrast to most of the DBS literature on convulsive seizures. The results also demontrate a modulatory role of the MD nucleus on absence seizures.
Исследование противосудорожного действия новой наносомальной внутривенной лекарственной формы карбамазепина.