Российская академия наук


Neurophysiological indici of severity and prognosis of efficacy of treatment of depressions



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Neurophysiological indici of severity and prognosis of efficacy of treatment of depressions

Iznak A.F.1, Iznak E.V.1, Yakovleva O.B.1, Safarova T.P.1, Sorokin S.A.1, Damyanovich E.V.1, 2,

Baziyan B.H.2

1Mental Health Research Centre of Russian Academy of Medical Sciences, Moscow, Russia,

2Research Centre of Neurology of Russian Academy of Medical Sciences, Moscow, Russia, iznak@inbox.ru
With the aim to reveal neurophysiological correlates and possible predictors of efficacy of psychopharmacotherapy of endogenous depression 50 patients (age 22-72) with diagnoses of depressive state in recurrent depression (F33.1 by ICD-10) or depressive phase of bipolar affective disorder (F31.3 by ICD-10) were examined following contemporary ethical norms of biomedical research.

Resting EEG, and auditory event related potentials (in odd ball paradigm) were recorded, and simple and choice reaction times to auditory stimuli were measured in all patients twice (before and after 28 days of treatment). Clinical conditions were assessed quantitatively using HDRS-17, CGI-S and CGI-I rating scales.

Pronounced improvement of clinical condition after 28 days of treatment was associated with EEG signs of left hemispheric frontal regions activation, and of increase of inhibitory processes in frontal-temporal zones of the right hemisphere, as well as with decrease of peak latency of “late” components (P2, N2 and P3) of auditory event related potentials and sensory-motor reactions time. According to correlation analysis data, lower values of initial (before treatment) beta-1 and beta-2 EEG spectral power in most EEG leads, and higher velocity of cognitive processes in the form of shorter values of peak latency of P2 and P3 waves of auditory event related potentials in central, temporal and parietal regions, and of shorter choice reaction time and “central delay”, associated with better scores (by HDRS-17, CGI-S and CGI-I rating scales) of patient’s clinical condition after 28 days of treatment.

Thus, these neurophysiologic and psychophysiologic parameters may appear to be the perspective predictors of biological aspects of efficacy of treatment of depressions.



The study is supported by Russian Humanitarian Research Foundation (grant No.12-06-00019).

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