Российская академия наук


Dynamics and relationships of neurobiological parameters in treatment of affective-delusional conditions



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Dynamics and relationships of neurobiological parameters in treatment of affective-delusional conditions.

Iznak E.V.1, Iznak A.F.1, Klyushnik T.P.1, Abramova L.I.1, Oleichik I.V.1, Ryabchikova N.A.2, Stolyarov S.A.1

1 Mental Health Research Centre of Russian Academy of Medical Sciences, Moscow, Russia,

e-mail: ek_iznak@mail.ru; 2 M.V.Lomonosov Moscow State University, Moscow, Russia


The goal of the study was is to reveal some neurobiological correlates of efficacy of treatment of affective-delusional conditions.

Resting EEG was recorded, and plasma levels of auto antibodies to nerve growth factor and to basic myelin protein were measured twice (before treatment and at the stage of remission establishing) in 2 groups of patients (by 10 persons, all females, age 22-65) suffered with depressive-delusional (group 1) or manic-delusional (group 2) disorders. Clinical condition of patients was assessed quantitatively using Hamilton’s depression rating scale (HDRS-17), Young’s mania rating scale (YMRS), and positive and negative symptoms rating scale (PANSS). All patients were administrated with adequate syndrome based pharmacotherapy.

Decrease of EEG slow-wave (theta and delta) spectral power in the first group, and it’s increase in the second group were noticed with improvement of clinical conditions by the end of the treatment course, while the pronounce of beta activity was decreased in both groups of patients. Correlation analysis has revealed statistically significant links of clinical rating scales scores before and at the end of treatment course with values of theta-2, alpha-1 and alpha-3 EEG sub-bands spectral power in the first group, and with values of spectral power of all EEG sub-bands (in 2-30 Hz band) in the second group, and with plasma levels of auto antibodies to nerve growth factor and to basic myelin protein, as well.

The data obtained are discussed in the frame of the role of neuroplasticity and of brain inhibitory systems in pathogenesis of affective disorders of different polarity.



The study is supported by Russian Humanitarian Research Foundation (grant No.12-06-00019).

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