Российская академия наук


Behavior of mice after exposure to nanosecond pulse-periodic X-rays of the brain



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Behavior of mice after exposure to nanosecond pulse-periodic X-rays of the brain

Kereya A.V.1,2, Bolshakov M.A. 1,2, Zamoshchina T.A.1,3, Knyazeva I.R.2,3, Kutenkov O.P.2, Semjonova Yu.N.1, Rostov V.V.2

1National research Tomsk state university, Tomsk, Russia; 2Institute of High-Current Electronics SB RAS, Tomsk, Russia; 3Siberian state medical university, Tomsk, Russia, kereya21@mail.ru
The appearance of the sources of nanosecond pulse-periodic X-ray radiation with pulses from a few to tens of nanoseconds initiated a study of the biological effects of pulse-periodic X-ray, including the effects on the CNS. Therefore, the purpose of presented work was to investigate the influence of pulse-periodic X-ray on the brain activity of mice and analysis of the effect on the emotional and behavioral components.

Experiments were carried out on 108 white male mice weighing 25-30 g. All ethical norms and rules were complied. Head of the animal was subjected to daily (for 10 days) exposure to 4000 pulses with a pulse repetition frequency 3, 6, 8, 13, 16 and 22 pulse per second (pps) (4 ns pulse duration), and the body of mice housed in a lead screen. The animals received doses per session 0.02 and 0.1Gy (accumulated over 10 days dose 0.2 and 1 Gy). The source of pulse periodic X-rays was the electron accelerator «Sinus 150» (Artemov K.P. et al., 2004). The experiment involved the irradiated and sham-irradiated animals. The emotional and behavioral components were assessed (horizontal and vertical components, mink activity, grooming and defecation) on how to «open field» (Buresh Ya. et al, 1991) before and after irradiation of mice.

Experiments have shown that the influence of nanosecond pulse-periodic X-ray may have a significant impact on some of the behavioral responses of irradiated mice. The inhibition of the horizontal (at 30-40%) and mink (25-60%) activities without changing the emotional status of the animals was observed after exposure to a dose of 1 Gy at 8, 13, 16 and 22 pps. Exposure to the same dose, but at a repetition rate 3 and 6 pps increased the vertical activity at 20-30% as compared with the sham-irradiated animals. After exposure to a dose of 0.2 Gy with frequencies 13 and 16 pps was an increase of vertical activity at 20-30% and of the number of bowel movements at 25-60% as an indicator of the emotional component. These results indicate that the nanosecond pulse-periodic X-ray affects brain activity in mice, and the effect depends on the pulse frequency and dose.

This work was supported by RFBR grant 12-04-32046.


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