Российская академия наук


Heart rate variability parameters of inbred rats depending on gender identity



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Heart rate variability parameters of inbred rats depending on gender identity

of individuals and their behavioural activity in the test «an open field»

Kuryanova E.V., Ukad A.S.

The Astrakhan state university, Astrakhan, Russia, fyzevk@rambler.ru


The present work aims the identifying of gender, typological features and interrelations of parameters of orientative - exploratory behaviour (OEB) and heart rate variability (HRV), with account of the primarily neurogenic nature of these vital activity displays (Sudakov, 2005; Baevsky, 2001). OEB was studied in the test «an open field» under the condition of 2 min exposition (Buresh at al., 1991), HVR was analyzed during the quiet wake with the help of the device "Varicard" and programs "ISKIM6" (Russia) at 35 male and 33 female adult inbred rats. OIB and HRV parameters of each animal unit were registered at the interval of not more than 30 min. All animals have been tamed. Statistical data processing have made with the help of software package Statistica 6.0.

OEB analysis show, that in contrast to males, female rats display more activity in the test «an open field», cross more peripheral squares (20,3 against 16,3, р<0,05), more frequent make the sets (3,6 against 2,7 р<0,05). The basic activity of the animals was calculated by the sum of the number of crossed peripheral and middle squares, peripheral and middle sets. . Due to this sum, there were chosen 3 groups of units with the different behavioral arousal: low (LBA, <20 displays), middle (MBA, 20-29 displays), high (HBA, >30 displays). Among the male rats, there were LBA-16, MBA-14 and HBA-5. Among the female rats, there were LBA-5, MBA-13 and HBA-14. Thus, the low active individuals are many (46 %) among male rats, and the high active individuals are many (42 %) among females.

HRV examination demonstrates, that female rats are differ from males in high heart frequency (р<0,01), АМо and stress index of Baevsky (р<0,05), and also lesser capacity of HF-waves (р<0,2). HRVanalysis displays according to the behavioral activity of the individuals, that males with HBA have higher parameters of the general variability of heart rhythm, than individuals with LBA and MBA: ∆Х (48,2 against 35,2 and 32,8 msec, р<0,05), SDNN (10,6 against 6,5 and 7,5 msec, р<0,05). HVR differences between similar female groups are not essential. Previously we (Kuryanova, 2009, 2011) have shown that there is a presence of individuals among the rats with the dominating (D) in spectrum HVR HF-, LF- or VLF-waves: DHF, DLF and DVLF. It was found, that among male rats with LBA 62 % of individuals have DHF and 25 % with DVLF, in the group of MBA rats there are 50% with DHF and 29% with DVLF, in the group of HBA individuals there are 40% with DHF and 60% with DVLF. In its turn, among the female rats of the LBA group, there are 40% individuals with DHF 20% and DVLF, in the group of MBA rats there are 54% with DHF and 46% with DVLF, in the group of HBA individuals there are 36% with DHF and 43% with DVLF. Rats with DLF were few in number.

Thus, female inbred rats are differ from males in high level of OIB, high heart frequency and lower of variability of heart rhythm. The consistency is observed among the male rats: the heart rate variability raises with growth of behavioural activity. Among male and female rats with high of behavioural activity the individuals are frequently meet with high contribution of VLF-waves into the general capacity of spectrum HVR what conforms to the concept of supersegmental nature of VLF-waves of HRV spectrum.



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