Metabotropic glutamate receptors (mGluRs) was found in the mammal brain in the 80's of last century. Eight different types of mGluRs, labeled mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity. mGluRs participate in modulation of synaptic plasticity, cognitive activity and adaptation processes. Disturbances of mGluR1/5 functions lead to neurodegenerative diseases associated with cognitive disorders (Alzheimer’s disease, Parkinson’s disease, schizophrenia and other) (Hovelso et al., 2012; Menard and Quirion, 2012).
The first information on the mGluRs in insect appeared at the end of the last century. In the honeybee was identified and localized 2 types of mGluRs: AmGlurA and AmGluRB. AmGlurA and AmGluRB are similar to mammal IimGluR2,3 (Funada et al., 2004). In this work we were identified and localized the mGluR1/5 and researched the mGluR1/5 role in the memory formation. We shown that mGluR1 localized in calices, mGluR5 in Kenyon cells of mushroom bodies in charge of integrative activity of insect. Western blotting was shown one band ~140 kDa (similar to mammal mGluR1). DHPG, CHPG, CPCCOEt, SIB 1757, MPEP and antisense oligonucleotides administration displayed what mGluR1/5 promoted long-term memory storage.
Thus, in the honeybee brain present mGluR1/5 of I group, which are pharmacologically similar to mammals. So the honeybee can be used as a model for drug screening whose target are mGluR1/5.