It is known that the most important mediator of neuroimmune interactions that can affect the structure of the central nervous system and increase vagal afferent activity is IL-1β, the main pro-inflammatory cytokine. Systemic levels of IL-1β dramatically increases in patients with chronic obstructive pulmonary disease, sleep apnea syndrome, as well as in healthy people with prolonged inspiratory breath with additional resistance. These data suggest involvement of IL-1β in the mechanisms of regulation of respiration.
The aim of this work was to study the effect of increased levels of IL-1β on mechanoreceptor regulatory mechanisms mediated Hering-Breuer reflex, which provides an implementation of space-dependent feedback in the respiratory system.
On anesthetized Wistar rats before and after systemic administration 5mkl solution containing 500ng of IL-1β, was recorded inspiratory fluctuations in intrathoracic pressure pnevmotahogrammy. State inspiratory-inhibitory reflex was tested by the normalized increase of the amplitude and duration of inspiratory IOP fluctuations in the first respiratory cycle after occlusion of the airway at the end of exhalation.
Found that systemic administration of IL-1β after 35-40 min leads to a significant increase of up to 15%, respiratory rate of 12% as a result of the MOU by 27%. Testing inspiratory-inhibitory reflex before and after administration of IL-1β showed a significant increase in normalized duration postocclusion inhaling up to 235% and 170% of the background rate.
Thus, the results of the pilot study indicate the immune system involved in the regulation of respiratory function. Increase system-level IL-1β causes a change in both frequency and volume components breathing pattern, the consequence of which is to increase ventilation. The observed modulation of inspiratory force-inhibiting Hering-Breuer reflex by the action of IL-1β is evidence of its involvement in the control of respiratory mechanoreceptor.