Российская академия наук


NEUROPROTECTIVE PROPERTIES OF NANOSTRUCTURES BASED ON C



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NEUROPROTECTIVE PROPERTIES OF NANOSTRUCTURES BASED ON C60, AND ANALOGS OF DIMEBON

DV Mischenko1, AV Smolina1, RA Kotelnikova1, DA Poletaeva1, II Fayngold1, VV Grigorev2, AV Bolkunov2, VL Zamoyskiy2, VS Romanova3, AI Kotelnikov1, SO Bachurin2

1 Institute of Problems of Chemical Physics RAS, Chernogolovka, Russia; mdv@icp.ac.ru

2 Institute of Physiologically Active Compounds RAS, Chernogolovka, Russia

3A.N.Nesmeyanov Institute of Organoelement Compounds RAS, Moscow, Russia
Donor-acceptor and photophysical properties of fullerenes depend on the spatial and electronic structure are known. Hybrid nanostructures with defined physiological activity, in particular neuroprotective can be obtained by adding to the fullerene spheroid different ligands. Consequently, the creation of fullerene-based hybrid nanostructures for the treatment of neurodegenerative diseases is promising. Such nanostructures are adducts to the fullerene spheroid two ligands, one of which is an amino acid that provides solubility in water, and the other - a substance having neuroprotective and / or cognitive boost the activity.

Molecular mechanisms of neuroprotective action of hybrid structures based on C60 (HSF) and cognitive-stimulating agents - an analog of the drug Dimebon (BD-2) were studied. It was found that the HSF and DB-2 exhibits antioxidant activity, increases the catalytic action of membrane-bound enzyme monoamine oxidase A and B. Fullerene hybrid structure with a BD-2 as the ligand does not show adverse stimulating effect, in contrast to itself BD-2, which can be useful for the spectrum of pharmacologically active substances. Substance BD-2 and investigated HSF have the same effect on the memory of animals.

Thus, the creation of HSF and the pharmacologically active groups can be one of the ways to optimize therapeutically promising compounds/

This work was supported by RFBR №12-04-31678 mol_a and program of the Presidium of RAS № 21

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