Российская академия наук


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Nazarov N.G.1,2, Zueva I.V.1, Vyshtakalyuk A.B.1, Reznik V.S.1, Zobov V.V.1,2

1A.E. Arbuzov Institute of Organic and Physical Chemistry Kazan Scientific Centre Russian Academy of Sciences, Kazan, Russia; 2Kazan (Volga region) Federal University, Kazan, Russia; zobov@iopc.ru
Adverse environmental factors and life of the inhabitants of modern Russia promote growth of diseases associated with liver function violation - an organ that provides the energy and the plastic needs of the body and performs detoxifying function. The situation is complicated by the absence in the russian domestic market hepatoprotectors, improve metabolic processes in the liver, increase its resistance to adverse effects, and promote recovery of liver function after various injuries.

The aim of this study was to investigate the hepatoprotective properties of the tissue regeneration stimulant - a russian drug "xymedon". This investigation can expand range application of this drug.

In our experiments it were used 30 laboratory rats weighing 250-400 g and 45 mice weighing 12-27 g in accordance with the rules of bioethics. Toxic hepatitis was induced by subcutaneous (2 ml / kg) or oral (4 or 5 ml / kg) administration of CCl4 solution dissolved in olive oil at a volume ratio of 1:1. Experimental groups were orally administered xymedon in doses of 5, 10, 50 and 100 mg / kg: for 4 days, 1 hour prior to subcutaneous infusion CCl4 (1 protocol) and within 4 days prior to a single oral administration of the CCl4 solution (2 protocol). As a control was a group with the same effect of CCl4, but with injection of the water instead xymedon.

Xymedon at dose 50 mg / kg reduce mice mortality twice in the experiments with second protocol (80% mortality in a control group, 40% in an experimental group) and weight loss in experiments with first protocol (0,29 ± 0,04 g weight gain per day in control group, 1,08 ± 0,10 g per day in experimental group, the differences are significant at p <0.001). In the study of blood biochemical parameters it was revealed a change indicates about synthetic dysfunction and destruction of liver cells in the control group of rats. Reduction of glucose, elevated activity of transaminases (p <0.01) - alanine aminotransferase and aspartate aminotransferase were observed. In the experimental group of rats with a similar effect of CCl4 but after pretreatment with xymedon (50 mg / kg), there

were no statistically significant differences with healthy animals. It was shown that degree of morphological liver violations in group which pretreated with xymedon were less then in a control.

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