Российская академия наук


IMMOBILIZATION STRESS AND CELL-FREE DNA LEVEL IN CEREBROSPINAL FLUID OF RATS



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IMMOBILIZATION STRESS AND CELL-FREE DNA LEVEL IN CEREBROSPINAL FLUID OF RATS

P.E. Umriukhin1³, O.S. Grigorchuk1³, K.V. Glebova2, N.N. Veiko2, K.V. Sudakov1³

1Sechenov First Moscow State Medical University, 2Research Centre for Medical Genetics, RAMS, ³P.K. Anokhin Institute of Normal Physiology, RAMS
Emotional stress increases the concentration of cell free DNA (cfDNA) – the biomarker of pathological processes in an organism that may result in different effects on physiological parameters. It is not known if such effect of stress may or not be observed in the cerebro-spinal fluid (CSF). The goal of the present study is to investigate the effect of immobilization stress on cfDNA level in the CSF of rats with the different locomotor activity in the open field test. Liquor was taken under chloral hydrate anesthesia from cisterna magna twice (before and after 2.5 h immobilization) with 10 day interval between probes. No significant differences were found in cfDNA concentration between groups of rats before immobilization. After stress CSF cfDNA level in active, but not passive rats, reduced in 1.6 times. In active rats inversely proportional correlation was found between liquor volume and cfDNA concentration (Spearmen correlation coefficient r = -0.82, p<0.001). Therefore our data may indicate the development of compensatory effect in active animals in response to the circulation decrease during emotional stress.

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