Российская академия наук


THE EFFECT OF THYMULIN ON ACTIVITY GAD AND GABA-T IN RAT BRAIN



страница77/848
Дата10.12.2019
Размер1.98 Mb.
1   ...   73   74   75   76   77   78   79   80   ...   848
THE EFFECT OF THYMULIN ON ACTIVITY GAD AND GABA-T IN RAT BRAIN

N.N. Aliyeva

Institute of Physiology n.a. AI Karaev NAS of Azerbaijan, Baku, nazaket-alieva@mail.ru


Between nervous and immune systems determine close relation. The mutual regulatory effects of immune and neuroendocrine systems becoming and functional implemented from embryonic development in all the period of life. In the various stages of ontogenesis the functions of these systems are different.

Study of the effect of hormones of the thymus on neurotransmitter amino acids in various brain regions is interesting interactions in solving the fundamental problem of the neuroendocrine-immune

In order to identify of the changes in the content of GABA in the brain tissue, it was necessary to study the activity of enzymes involved in the synthesis (glutamate acid decarboxylase (GAD)), and the splitting of the GABA (GABA-amintransferaza (GABA-T)). That's why the activity of GAD involved in the synthesis and activity of GABA-T - splitting and absorption of GABA in the brain structures of 10-day-old white rats after a single injection thymulin rate of doze 20 mg/kg were studied.

Experiments showed that the enzyme activity in the tissues of GAD of the structures of the brain in 10-day-old rats after single injection thymulin 20 mg/kg increases (in the cerebellum - 28% (p<0.05), hypothalamus - 45% (p<0.001), the visual cortex of the brain - 38% (p<0.05), the motor cortex - 32% (p<0.05) relative to controls). The activity of GABA-T in the tissues of the structures of the brain in 10-day-old rats after injection thymulin 20 mg/kg decreases (in the cerebellum - 15% (p<0.05), hypothalamus - 26% (p< 0.01), the visual cortex of the brain - 20% (p<0.05), the motor cortex - 19% (p<0.05) compared to control animals).

Comparing the degree of influence of thymic peptides on the enzyme activity of GAD and GABA-T in the studied brain regions, we can note that the effect of thymic peptides on GABAergic neurons are generally more pronounced. It is established that, the thymic peptides have a direct effect to the hypothalamus. In addition, it should be noted that, as mentioned above, the hormonal system of the hypothalamus and pituitary mechanisms

involved in the positive or negative feedback loop to regulate the synthesis and secretion of thymic peptides by epithelial cells of the thymus.

The results in this experiment suggest that the hormones of the thymus are able to exert some influence the pool of amino acid in the different structures of the rat brain and plays role in the physiological functions of the central nervous system and all the body during in early postnatal development.


Каталог: news
news -> Умеренные когнитивные нарушения у больных с сосудистым поражением головного мозга 14. 01. 11 нервные болезни
news -> 15-й международный медицинский форум «качество и безопасность оказания медицинской помощи» нижегородская ярмарка россия, Нижний Новгород
news -> Сборник материалов
news -> Разработка технологии вкусоароматических добавок с применением сенсорных технологий
news -> «казұму 85 жыл: жетістіктері мен келешегі» халықаралық ғылыми-тəжірибелік конференция аясындағы «клиникалық фармация: халықаралық ТƏжірибе мен қазақстанның денсаулық сақтаудағы даму ерекшеліктері»
news -> Программа международной научно-практической конференции 14-15 апреля 2016 г. Курск 2016
news -> Российская академия наук отделение физиологических наук


Поделитесь с Вашими друзьями:
1   ...   73   74   75   76   77   78   79   80   ...   848


База данных защищена авторским правом ©zodorov.ru 2017
обратиться к администрации

    Главная страница