¹Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, Saint-Petersburg, Russia; ² The State Pavlov Medical University, Saint-Petersburg, Russia; firstname.lastname@example.org.
Patients with end-stage renal disease (ESRD) under hemodialysis are distinguished by the presence of chronic pain and itching. Audio-therapy is a non-invasive psychocorrection technique effective when working with patients of this group. Subjective scales of pain, anxiety, and depression have been used so far to estimate the effects of music therapy on patients. In this study, the numerical estimation of audio-therapy effect was used, namely thresholds of tactile sensitivity and post-stimulus pain in healthy subjects and in patients with ESRD under hemodialysis.
Using focused ultrasound, the thresholds of tactile sensitivity and post-stimulus pain in healthy people and patients with ESRD under chronic hemodialysis have been measured. 8 of 19 such patients received psychotherapeutic correction (audio-therapy). Also, the mental state of patients has been estimated by Spielberg-Hanin testing, Beck scale, and visual analog pain and itch scales.
It has been found that the tactile sensitivity threshold in thirteen patients is higher than in healthy subjects, in four patients - below, and two - at the level of healthy people threshold. Post-stimulus pain thresholds in fourteen people are above normal, four - below, and one - at the norm. The psychotherapeutic correction in patients has combined with increasing of thresholds of tactile sensitivity and post-stimulus pain and with decreasing of numerical differences between these thresholds. Statistically significant decrease of anxiety and depression has been observed during the audio-therapy.
These data indicate that the intensity of post-stimulus pain in ESRD is defined by psychic component, and the tactile sensitivity is less dependent on the levels of anxiety and depression in comparison to pain.
The research is supported by RFH grant 12-06-0048.