Российская академия наук


MOLECULAR MECHANISMS OF PATHOGENESIS OF ALCOHOLIC MYOPATHY



страница801/848
Дата10.12.2019
Размер1.98 Mb.
1   ...   797   798   799   800   801   802   803   804   ...   848
MOLECULAR MECHANISMS OF PATHOGENESIS OF ALCOHOLIC MYOPATHY

B.S. Shenkman

State Scientific Center of Russian Federation – Institute for Biomedical Problems,

Russian Academy of Sciences, Moscow, Russia
Chronic alcoholic myopathy is one of most numerous and profound manifestations of chronic alcohol intoxication. This disease is characterized by the pronounced atrophy of the locomotor muscles, which involves predominantly those fibers expressing myosin isoforms of the II “fast” type. At the same time patients at the early stages of the disease development not always demonstrate signs of fiber atrophy. In early experiments with alcohol-fed rats it was shown the impairment of the anabolic intracellular signaling pathways and decrease in protein synthesis rate. However the alterations of the signaling pathways in muscles of patients with alcoholic myopathy are not studied yet. In our lab we were the first to analyze the signaling pathways involved in the pathogenesis of alcoholic myopathy with different fiber atrophy levels. In biopsy samples of m. vastus lateralis (even at the early stages of the disease) we found dramatic drop of the phosphorylation levels of S6 ribosomal kinases and increase in phosphorylation of the eukaryotic elongation factor-2, which facilitate the decrease of the protein synthesis levels. At the early stages we observed also the significant increase of mRNA of E3 ubiquitin ligases. However the ubiquitinylation level was not altered in patients as compared to the control subjects. This phenomenon could be associated with the increased expression of the heat-shock proteins, known for their protective action. Thus in patients with alcoholic myopathy we revealed the impairment of the anabolic as well as catabolic signaling pathways in skeletal muscle. The study was performed in collaboration with the Neurological Clinic of the Sechenov First Moscow State Medical University and funded by the Program of the RAS Presidium “Basic Sciences for Medicine”.


Каталог: news
news -> Умеренные когнитивные нарушения у больных с сосудистым поражением головного мозга 14. 01. 11 нервные болезни
news -> 15-й международный медицинский форум «качество и безопасность оказания медицинской помощи» нижегородская ярмарка россия, Нижний Новгород
news -> Сборник материалов
news -> Разработка технологии вкусоароматических добавок с применением сенсорных технологий
news -> «казұму 85 жыл: жетістіктері мен келешегі» халықаралық ғылыми-тəжірибелік конференция аясындағы «клиникалық фармация: халықаралық ТƏжірибе мен қазақстанның денсаулық сақтаудағы даму ерекшеліктері»
news -> Программа международной научно-практической конференции 14-15 апреля 2016 г. Курск 2016
news -> Российская академия наук отделение физиологических наук


Поделитесь с Вашими друзьями:
1   ...   797   798   799   800   801   802   803   804   ...   848


База данных защищена авторским правом ©zodorov.ru 2017
обратиться к администрации

    Главная страница