Российская академия наук


Energy support and energy spending of brain in the assembling of the emotional-motivation state under vitamin deficiency



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Energy support and energy spending of brain in the assembling of the emotional-motivation state under vitamin deficiency

Askerov F.B., Movsumov Q.J., Abushov B.M., Azimova A.M., Panakhova Kh.Q., Kadimova S.O.

Institute of Physiology n.a. A.I.Karayev NAS Azerbaijan, Baku, fbaskerov@box.az


The findings showed that Na, K- ATPase activity is decreased in the hipotalamus (H)and sensorimotor cortex (SMC) (by 25 and 32% correspondingly) under 20-day vitamin-free diet (VFD), while Mg- ATPase activity is increased in H (by 7%) and decreased in SMC (by 36%) as compared to the controls. Under 30 day VFD Na, K- ATPase activity decreases in H and SMC (by 20 and 30% correspondingly), while Mg- ATPase activity increases in H (by 11%) and it decreases (by 32%) in SMC .

In this case noticeable decreasing of succinatdehydrogenase (SDH) activity occurs in H and SMC (by 24 and 46% correspondingly). The experiments showed that under 20- day VFD lactatdehydrogenase (LDH) activity in H and SMC homogenates is decreased to 70 and 80% correspondingly; while in mitochondrial fractions it is decreased to 24 and 48% correspondingly. At the same time its activity is increased in cytozole to 118 and 137% correspondingly.

Under 30 day VFD LDH activity in H and SMC homogenates is increased to 183% and 141% correspondingly; in the cytozole fraction its activity increases to 184% and 121% correspondingly while in mitochondrial fractions it decreases to 44 and 71%.

The obtained findings indicate that under 20- and 30 day VFD brain goes over to alternative energy support mechanisms, that is from gluconic to lactate cycle. This is markedly manifested in the decreasing the activity of the enzymes implicated in energy support and energy spending mechanisms of Na, K- ATPase, SDH and in increasing of LDH activity in cytozole fraction of H and SMC homogenates. Under oil-soluble VFD with retention of water- soluble vitamins in the diet the activity of aerobic isofraction of LDH (LDH1,2) is decreased in the cytozole, while its anaerobic fraction(LDH4,5) and intermediate isofraction(LDH3) increase. These findings indicate that in the studied brain structures energy support is realized by oxidative phosphorylation of metabolites in brain tissues.

Proceeding from the foregoing, water- soluble vitamins play an important role in energy support, while oil-soluble vitamins – in the processes of energy supply of plasmatic neuronal membranes.

So, under VFD energy supply and energy support processes are destroyed which produces a disturbance of the mechanisms of extraction of instinctive memory traces out of genetic apparatus and desensitization of plasmatic membrane receptors.

The absence of oil-soluble vitamins causes positive emotional state, while water- soluble VFD causes negative emotional state in the animals’ behaviour.


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