Российская академия наук


THE INFLUENCE OF FORCED HYPOTHERMIA DIFFERENT DEPTH AND DURATION ON LIPID PEROXIDATION IN BLOOD OF RAT



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THE INFLUENCE OF FORCED HYPOTHERMIA DIFFERENT DEPTH AND DURATION ON LIPID PEROXIDATION IN BLOOD OF RAT

Astaeva M.D., Ismailova J.G., Radjabova Z.G., Abdulzhalilova D., Emirbekov E.Z.

Dagestan State University, Makhachkala, Russia, mashia@mail.ru
The influence of hypothermia leads to the activation of oxidative processes, and as a result increase the free-radical processes in animals. Increase free-radical processes initiated the damaging effect of low temperature on biostructures and their normal functioning. In this regard, relevant studies on adaptation to intermittent cold exposure in the dynamics of hypothermia varying depth and duration.

We investigated the influence of forced hypothermia varying deep and duration of the content of malondialdehyde in blood of rat. Method for the determination of malondialdehyde by reaction with thiobarbituric acid is one of the methods to assess lipid peroxidation. Found that a single mild (30°C) and deep (20°C), hypothermia leads to increased accumulation of malondialdehyde by 26% and 11%, respectively, in agreement with literature data.

Repeatedly mild (30°C) hypothermia found that the content of MDA is on par with the intact control, which seems to come to an adaptation to hypothermia. Mild (30°C) single hypothermia after repeated moderate (30°C), hypothermia resulted in a sharp (by 40,76%) reduction in the accumulation of malondialdehyde in rat plasma, and in the case of deep (20 ° C) hypothermia after repeated moderate (30°C) hypothermia content of malondialdehyde in plasma does not change significantly.

Thus, multiple moderate (30°C), hypothermia leads to normalization and to reduce the content of MDA in plasma of blood, which is the criterion efficiency adaptability of the body at low temperatures.

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